Drug sensitivity prediction

Drug sensitivity prediction.

Barretina J et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483:603 (2012).

Abstract - What is the study about and why was it performed?

What is a cancer cell line? See

Which genomic profiles were generated?

Are cell lines good models for real tumours? Figure 1.

What are pharmacological profiles, how is drug sensitivity measured?

What is predictive modelling, how were robust models derived, what is shown in Figure 2?

Ghandi, M., Huang, F.W., Jané-Valbuena, J. et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569, 503–508 (2019).