Statistical significance
Statistical significance for genome-wide studies.
Categories:
Classic paper
Storey, John D., and Robert Tibshirani. “Statistical significance for genomewide studies.” Proceedings of the National Academy of Sciences 100.16 (2003): 9440-9445.We cover the following parts:
- Abstract
- Example 1, differentially expressed genes
- Table 1
- What is a p-value?
- What is the FDR?
- Derivation that p-values are uniformly distributed under the null hypothesis
- Figure 1
- FDR estimation
- Figure 2
- What is a q-value?
Fig 1. Density histogram of p-values
A density histogram of $p$-values. Figure obtained from full text on EuropePMC.
Last modified May 30, 2023: update Gaussian processes (ff6a6c2)