Adriaan’s paper “Comparison between instrumental variable and mediation-based methods for reconstructing causal gene networks in yeast” has been posted on biorXiv. In this paper we used Findr to compare several methods for causal inference from genomics and transcriptomics data, using a recently published dataset of 1,012 segregants from a cross between two budding yeast strains.
Very pleased that the Norwegian Research Council will fund our project “Intelligent systems for personalized and precise risk prediction and diagnosis of non-communicable diseases” as part of its IKTPLUSS initiative.
The aim of this project is to create computer methods for risk prediction and diagnosis of non-communicable diseases using multi-omics data, by developing, implementing and validating novel algorithms for structure learning and inference in large-scale, multi-organ causal Bayesian gene networks. The project will integrate unique multi-omics data from three Nordic studies for a proof-of-concept application in cardiovascular medicine:
The project partners are:
Lingfei’s paper, “High-dimensional Bayesian network inference from systems genetics data using genetic node ordering” has been published in Frontiers in Genetics, in a Special Topic on Machine Learning and Network-Driven Integrative Genomics.
In this paper, we present a highly efficient approach for reconstructing Bayesian gene regulatory networks when prior information for the inclusion of edges exists or can be inferred from the available data. The method is implemented in the Findr software.
Pau’s paper “Model-based clustering of multi-tissue gene expression data” has been published in Bioinformatics. In this paper a method, called “revamp”, is introduced to find clusters (groups of genes with shared activity patterns) in multi-tissue data, where gene expression profiles are available from multiple tissues or organs sampled from the same group of individuals. Revamp improves existing methods by its ability to incorporate prior information on physiological tissue similarity, and by identifying a set of clusters, each consisting of a core set of genes conserved across tissues as well as differential sets of genes specific to one or more subsets of tissues. Revamp is implemented in the Lemon-Tree software.
A belated but nevertheless very warm welcome to Adriaan and Wouter who joined the group in October!
Adriaan is a postdoc with master and PhD degrees in physics who most recently worked as a postdoctoral researcher in the neurophysics group of Jordi Soriani in Barcelona. His focus there was on network inference methods for neuronal activity data, and he will use that experience to further develop our causal gene network inference methods for applications in systems genetics.
Wouter is a master student in bioinformatics and systems biology in Amsterdam who is joining the group for a 6-month internship. He will work on a method for inferring data-driven gene ontologies from gene expression data.
Lingfei’s paper “Accurate wisdom of the crowd from unsupervised dimension reduction” has been published in Royal Society Open Science. In this paper it is shown that wisdom of the crowd, the collective intelligence derived from responses of multiple individuals to the same questions, is analogous to one-dimensional unsupervised dimension reduction in machine learning. This means that many of-the-shelf dimension reduction methods, such as good old PCA, can be repurposed as crowd-wisdom methods, usually with (much) better performance than existing default crowd-wisdom methods. Perhaps one of the more surprising results concerned the classification of skin images as being cancerous or not. As part of the hype surrounding deep learning, it was recently found that a deep neural network trained on 130,000 images was better at classifying a test set of 111 skin images than 21 individual dermatologists. However, we found that by doing a simple PCA of the predictions of these 21 dermatologists, they collectively outperformed the deep neural network. As The Economist put it in their recent ad, “not all intelligence is artificial”. In fact some of it is collective.
A warm welcome to Ramin Hasibi who has joined the group as a PhD student. Ramin has a master degree in computer networks and a strong background in deep learning and machine learning more generally. Welcome!
I’ll be at the EMBO symposium on regulatory epigenomics next week. Looking forward to it!
A warm welcome to Ammar Malik who has joined the group as a PhD student. Ammar has a degree in Computer Engineering and brings with him a lot of experience in machine learning. Welcome!