Findr preprint

We have posted a preprint “Efficient causal inference with hidden confounders from genome-transcriptome variation data”. In this paper we introduce a new method for causal inference between gene expression traits using the DNA variations in cis-regulatory regions as causal anchors. The method has been implemented in the Findr software, and validated using the DREAM5 Systems Genetics Challenge and GEUVADIS datasets.

Welcome Pau!

A warm welcome to Pau Erola who joins us as a postdoctoral Research Fellow, having completed a PhD in Computer Engineering from the Universitat Rovira i Virgili and an MSc in Biomedicine from the Universitat de Barcelona.

Cell Systems publication

Update: Our paper has been selected for a Highlight presentation at ECCB 2016.

Update: Cell Systems has published an Editorial Preview of our paper.

Husain’s paper “Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease” has been published in Cell Systems, the new flagship systems biology journal from Cell Press. In this paper we reconstructed and analyzed regulatory gene networks across 7 vascular and metabolic tissues using genotype and gene expression data sampled from more than 100 individuals. Here’s the graphical abstract:

CAD-RGN-Cell-Syst-graphabstract.

Congrats Husain!